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Aug 2, 2005 · The function of SET-domain proteins is to transfer a methyl group from S-adenosyl-L-methionine (AdoMet) to the amino group of a lysine residue ...
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We show that the enzyme is exclusively a mono-methylase and is therefore responsible for a signaling role quite distinct from that established by other enzymes ...
Dec 7, 2023 · The SET domain bifurcated histone lysine methyltransferase 1 (SETDB1), also known as lysine N-methyltransferase 1E (KMT1E) or Erg-associated SET ...
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Two major types of histone methyltranferases exist, lysine-specific (which can be SET (Su(var)3-9, Enhancer of Zeste, Trithorax) domain containing or non-SET ...
Protein lysine methylation by SET domain enzymes regulates chromatin structure, gene silencing, transcriptional activation, plant metabolism, and other ...
Oct 21, 2002 · The catalytic domain of Clr4 consists of residues 192–490, which includes the conserved SET domain flanked by cysteine-rich pre- and post-SET ...
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In this study, we report that overexpression of MMSET in myeloma cells leads to aberrantly high global levels of H3K36 dimethylation, accompanied by a striking ...
Mar 5, 2020 · Most of HKMTases contain a conserved domain consisting of 130–150 amino acids with methyl transferring activity. This domain is named SET based ...
Here we described the characterization of SET DOMAIN GROUP 2 (SDG2), a large Arabidopsis protein containing a histone lysine methyltransferase domain. We ...
Apr 19, 2021 · Histone lysine methylation plays an important role in plant development and stress responses by activating or repressing gene expression.